ItBit (itbit.com) was launched in Singapore in 2012 as a provider of cryptocurrency exchange services.
Bitstamp (bitstamp.net) was launched in Slovenia in 2011 as a provider of cryptocurrency exchange services.
Global Digital Asset Exchange (GDAX, gdax.com) was launched as a cryptocurrency exchange, part of Coinbase, in 2015.
BTCbank (btcbank.io) provides Bitcoin investment services from the United Kingdom.
BTC Doubler (btc-doubler.com) provides Bitcoin investment services.